The Effects Of HIV Mutations On The Immune System Science C.J. Stimson

The Effects of HIV Mutations on the Immune System Science C.J. Stimson INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the host's chromosomes; they are thereby distributed to all daughte r cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to ?read? that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body - the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIV's Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from t he cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to The Effects Of HIV Mutations On The Immune System Science C.J. Stimson The Effects of HIV Mutations on the Immune System Science C.J. Stimson INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the host's chromosomes; they are thereby distributed to all daughte r cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to ?read? that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body - the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIV's Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from t he cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to

Discuss and Analyze The Events of The 1968 Democratic National Convention in Chicago and What Caused Them essays

Discuss and Analyze The Events of The 1968 Democratic National Convention in Chicago and What Caused Them essays The purpose of this paper is to introduce, discuss, and analyze the topic of American history. Specifically it will discuss the events at the 1968 Democratic National Convention in Chicago, and what caused them. The 1968 Convention in Chicago is remembered for its violent riots and government response to those riots. The problems in Chicago had roots in the Vietnam War, but the many causes went deeper than that. Vietnam helped create a division in the country, but the country was ripe for division and dissension. The postwar consensus in American society was highest in the 1950s when the economy was healthy, and most Americans were content. However, underlying the consensus was unrest in many areas. Teens, born in the war years were tired of following the strict mores of society. They rebelled by wearing jeans, listening to rock and roll, and opposing the morals of their parents. They wanted something different than suburbia, and so they tried to be more liberal and outspoken than their parents. This was the generation that would protest the Vietnam War, dabble in illegal drugs, and eventually rise up against the government and establishment. However, there was much more to the social rebellion that created such a rift in the country. While most white Americans were content in their lives, blacks, who had fought alongside whites in the war, came home to segregation, prejudice, and a lack of basic civil rights. They became increasingly discontent with their situation, and began to loudly protest for their Civil Rights. Their protests actually worked, and the Civil Rights bills of the 1960s ensured equal rights for blacks and other minorities. Seeing this success, others who were discontent with the government and the war in Vietnam used the same tactics to protest, but these protests began to turn violent and ugly. Blacks are killed in many riots, including riots following the assassination of Reverend Martin Luther K...

Strategic Human Resource Management Essay Example | Topics and Well Written Essays - 750 words

Strategic Human Resource Management - Essay Example This method of providing feedback has become quite popular because of the various benefits associated with it if it is carried out in the right manner, but still there are certain limitations associated with this method. The initiation of the process of 360-degree feedback starts when a particular leader perceives that he/she needs to further their development in order to meet the changing needs of the organization (Atwater, 2007, p.287). This means that the main purpose of conducting this form of performance appraisal is the purpose of development. This means that organizations that are implementing this feedback should focus on the developmental aspect associated with this form of feedback instead of focusing on the administration purpose of performance appraisal. Before implementing this performance appraisal method, organizations should take into consideration the current health of the organization. If the organization is going through the process of cutting cost and is decreasing their workforce, they should avoid using this form of appraisal as during such a situation organizations may fail to obtain objective information since employees will be trying to protect their own interests and jobs. Commitment towards the appraisal process is very essential and it is the job of the human resource departments to obtain commitment for the appraisal system. But the HR department is not only responsible for gaining commitment; they have to align other roles and duties along with acquiring commitment. This is because if the process is not associated with other roles, then the participants of the process may lose commitment and would find the process to be waste. According to Atwater, a research was conducted in which 19% of the surveyed organizations reported that if the 360-degree feedback system is not connected with human resource development practices, the participants who are being evaluated

A Letter to God by Gregorio Lopez Y Fuentes Essay

A Letter to God by Gregorio Lopez Y Fuentes - Essay Example However, the expected rain turned to hail and soon destroyed all his crops which placed his family in an anticipated hunger throughout the year. Thinking about his God whom he knows would provide for their needs, the farmer then writes a letter to him which he sent through the mail. In the amusement of the postman and the postmaster, the former tried to correspond with the farmer but found the task to be challenging when he opened the letter and found out that the farmer was asking for a hundred pesos in order to re-sow the fields and to live by while they wait until harvest time. The postmaster then made his best to raise the money but was able to just send seventy pesos. When the farmer received his mail, he was disappointed when he opened it seeing it was not the full amount he asked for. So he made another letter telling God he just received seventy pesos and asking him to send the full amount of a hundred pesos because he badly needs it. Moreover, he asked the money not to be se nt through the mail because the post office employees are crooks, thinking the thirty peso deficit was taken by them.

Enhancing Dementia Practice Essay Example | Topics and Well Written Essays - 2500 words

Enhancing Dementia Practice - Essay Example w of the most important strategies in Northern Ireland include: educating people about the possible signs and symptoms of dementia, creating a friendly community for people with dementia, creating public awareness about the importance of early diagnosis, integrating a wide-range of services that will support the specific needs of people with dementia, and extending necessary trainings and support of carers of people with dementia. Dementia is often characterised by having memory impairment and increased risk of having aphasia – language deficit, agnosia – perceptual disorder, and apraxia – motor functioning disorder (Mendez and Cummings, 2003, p. 6). Aside from having progressive memory loss, people with dementia can be very much disoriented (Gilmour and Brannelly, 2010). Likewise, there are cases wherein people with dementia experience cognitive deficit when it comes to comprehension and reasoning (Gilmour and Brannelly, 2010). Among the common types of dementia include Alzheimer’s disease (62%) followed by vascular dementia (17%), mixed dementia (10%), lewy-body dementia (4%), fronto-temporal dementia (2%), Parkinson’s dementia (2%), and others (3%) (Alzheimers Society, 2015a). As of 2015, roughly 20,966 people in Northern Ireland were diagnosed with dementia (Alzheimers Society, 2015a). By 2051, the number of people with dementia in Northern Ireland is expected to increase between 60,000 (Department of Health, Social Services and Public Safety, 2011) to 61,000 (DSDC, 2015). (See Figure I – Types of Dementia below) Almost half the number of people with dementia is receiving care and support in care homes (Department of Health, Social Services and Public Safety, 2011). To help improve the quality of health and social care services given to people with dementia, the Health Minister of Northern Ireland received a funding of  £6 million from the state government last September 2014 (Northern Ireland Executive, 2014).Through state funding, it is

Egyptians and Olmec Civilizations

Egyptians and Olmec Civilizations Egypt civilization will be the old world that I would be talking about. The Egyptian civilization had many ages which are early Bronze Age, middle bronze age, and late Bronze Age. The Egyptian civilization dates from the 4th millennium BC. It has a lot of arts and monuments that makes Egypt a unique place to visit. Many achievements were made by the Egyptians like the pyramids, temples, and obelisks. In the predynastic period Egyptian climate was much less dry than it is today. Most regions of Egypt were covered by savanna trees. In the early dynastic period the Egyptians had a long line of pharaohs from Menes. It has been said that the Egyptians had two kingdoms of upper and Lower Egypt. The first dynastic pharaohs solidified their control over Lower Egypt by making a capital at Memphis. Old kingdom and new kingdom will be talked about also. The Olmec civilization was started between 1200 and 400 b.c. The Olmec civilization was developed at San Lorenzo and the Olmec power moved to la venta. The Olmec was Mesoamerica`s first complex culture. The Olmec used the sacred 260 day calendar and a form of kingship that were later Mesoamerican cultures. The Olmec dated from 1400 BCE to about 400 BCE. The first major civilization in Mexico is the Olmec and they were known for the artwork. Monuments were also an important characteristic of Olmec centers. The culture of the Olmec was best known for sharing customs, history, beliefs, and other traits. Egypt Old World Civilization The Egypt civilization is known for the beautiful pyramids. Most people who think of Egypt think of the impressive Great Pyramids, Sphinx, Temples and ancient sites, but Egypt offers much more. It is romantic cruises down the Nile, the culture of Cairo, a night at the grand opera, a trek up Mt Sinai, the ancient monastery at St. Catherines, the popular diving and scuba diving Red Sea resorts, Alexandria and its surrounding beautiful beaches and Mediterranean resorts. Egypt also offers nature and desert treks, great scuba diving, fishing, golf, and birding expeditions. It is part of the Holy Land, and tours to Christian and other religious monuments are popular. Egypt is a land bustling with life, sound, visual beauty and excitement. For thousands of years, it has been the playground of emperors and kings, and now from tradition to modernity, Egypt is a country which has succeeded in creating a present that is as fascinating as its past. Egypt was one of the greatest civilizations tha t have ever existed with memorable monuments (Allen, 2009). Ancient Egyptian had a well-defined, deeply conservative ideology which was firmly based on doctrines of conformity, continuity, and precedent. Each pharaoh ruled not according to written law, but on the basis of precedents set by the gods and by earlier rulers. Egyptian ideology fitted the kings of the past and their great monuments into a majestic, linear scene. The early Egypt civilization developed a formalized style of painting and sculpture and was very spiritual and believed in life after death (Sayyid-Marsot, 2007). Early Egyptians participated in war dancing, gymnastic games, swimming and even wrestling. Children had toys which were dolls, tops, hoops, jumping jacks, skin or leather balls, marbles, and dice, the balls were mainly for ball games which were used by tossing and juggling. Religion The Egyptians as a race were profoundly religious. They recognized divinity in everything around them; the whole universe breathed of God. Birds reptiles, animals and trees were permeated with the divine essence; they saw God as a plurality in unity. The spirit of God was infused into everything, so the powers of Nature, the elements, were also divine, and was personified as the Elementals of earth, sky, air and water. Attributes and functions were also personified, sometimes in human, sometimes in animal form, which became, for the time being, the manifestation of a special attribute of deity, the abode of the God, the symbol of a power divine. Thus a multiplicity of gods is presented, which is at first confusing (britannica, unknown).To understand the subject, comparison must be made with the beliefs and religions of other lands, not only of the past but of the present Man of the inferior gods are seen to be parallel to angels and archangels, to spirits that assist mankind in his p rogress through this world and through the next, and are by no means to be confused with the great gods. Many of the deities are only aspects, forms, of God. The official religion of Egypt is Islam and most of the Egyptians adhere to its Sunni branch (britannica, unknown). Gods were worshiped in temples that were brought by priests that act on the king`s behalf. Also, Priests had a system of oracles to communicate the will of god to the people. The Egyptians did have a somewhat currency. There was a system that was used as a currency which was weights of gold, silver and copper. However, around 500BC there were coins as a currency (Sayyid-Marsot, 2007). Hedj which means money was close to what is called to be a currency that was used for exchange of money. The writing of the Egyptians was composed of many symbols which same symbols can serve different purposes. The Hieroglyphic writing was a formal script used on stone monuments and in tombs. The Olmec New World Civilization The Olmec is considered to be one of the greatest civilizations in Mesoamerica. The Olmec was traced to the area of San Lorenzo Tenochtitlan city. The first city for San Lorenzo was The Olmecs and it was an important civilization for around 500 years (Encyclopedia).Prior to the Olmecs, the Indians of Mexico were hunters and gathers. They were nomadic, spending very little time in one location. As soon as the animals they hunted became scarce in one area, they gathered the few belongings they had and moved to a new location with the hope of more plentiful game. When the Olmecs settled in southeastern Mexico, they established agricultural staples such as corn, squash and beans. They also constructed large cities, religious centers, and trade routes. They developed a distinct culture, characterized by highly developed art and religion (Rosenswig, 2010). The Olmec had a great run in history between 1200 B.C. and 400 B.C. Back in those days, they were the record setters in this part of the world. For example, they were the first in the Americas to develop a written language. And they were the first in the Americas to build pyramids. But sadly, many of their accomplishments have disappeared over time. Today, we know almost nothing about the Olmec and their amazing culture. As a matter of fact, we do not even know what they called themselves! The Aztec Indians gave the tribe the name Olmec. It means rubber people. The Aztecs called them this because the Olmec supplied them with sap from rubber trees. Apart from being known as the rubber people, the Olmec were equally famous for their colossal heads. Each colossal head was a sculpture carved out of a single block of stone. The stone was quarried in the Tuxtla Mountains. To date, we do not know for sure how the Olmec transported the stone and who the colossal heads were supposed to repres ent. Many researchers believe that the Olmec used rafts to carry the stone. And they made the colossal heads to portray their famous rulers. Thus far, scientists have unearthed more than a dozen colossal heads. They all had slanted eyes and large lips. The biggest one is about 3.4 meters tall. It weighs over 20 tons. The Olmec created several monuments which are colossal heads, Small Feline, Feline-Jaguar, cross legged pose, and many more. One of the similarities of the Egyptians and the Olmec is the monuments. The Olmec Center at San Lorenzo, Honduras, contains several huge carved heads. Some of them are 9 feet high and weigh about 40 tons. The heads may be portraits of Olmec leaders or of players in a sacred ball game. The stone used for the sculptures came from a site more than 250 miles away. The Olmec transported this stone over mountain ranges, rivers, and swamps. The Olmec altar has a carved figure at the base situated at the mouth of a cave. This figures elaborate headdress shows that he is a ruler. The ruler holds a rope that winds around the base of the altar and binds a carved figure at the back. Scholars believe that the altar was used as a throne (Encyclopedia). Differences between Egypt and Olmec The belief systems of the Egyptians and Olmec civilizations also had similarities and differences. Most of the people of Egypt practiced polytheism. Although this religion had many gods, it recognized one supreme god or life force. Like polytheism, the Olmec religion also had several gods. A rain god shown as half-human and half-jaguar dominated their religion. But unlike the Egyptians, the Olmec probably did not view this rain god as a supreme god. Both the Egyptians and Olmec built great temples for worship. Egyptian builders constructed many types of temples. One type had a square shape with a pillared front porch and a flat roof. The other type also had a square structure, but its roof had a pyramid shape. The Olmec constructed entire buildings that were pyramids and probably used them as temples. So two civilizations, thousands of miles apart with no direct connection, both used the pyramid shape for their houses of worship (Olmec Meso).

Mass Media :: Violence Technology Papers

Mass Media Part I: The Problem. In the aftermath of the Columbine school shootings, parents were eager to find someone or something to take the blame for the tragedy. We as Americans are a culture that has to be able to control the outcome of our everyday lives. When something happens that catches us off guard, we get frightened and jump to conclusions. With no closure in sight from the columbine shootings, parents across the country wanted answers. Instead of evaluating their own parenting, people began to say that video games, movie and television were the problem. The idea was that by eliminating the violence on TV and that will stop kids from being violent. The news media, fearing for its ratings took this idea and ran with it doing in depth stories and all types of special reports. The goal of this newsletter is not to place blame on anyone, but to bring to the realization that the only way to help our youth is to not blame outside factors for behavior but approach the problem directly, in the home, face to face with the child. Columbine: The tragedy On a sunny spring day in April 1999, a suburban high school in Jefferson County, Colorado, found itself under attack by two of its own. In less than fifteen minutes of the first-lunch period on that Tuesday, two student gunmen killed 13 and wounded 21 before they turned the guns on themselves in the most devastating school shooting in U.S. history. Columbine High School is one of three in the unincorporated southeast portion of Jefferson County. The county itself lies on the west side of the Denver metropolitan area and is the most populated county in the state. The large unincorporated region along the county’s southern plains and foothills has a population of nearly 100,000 residents - 1,945 of who attended Columbine High School. The two student gunmen were Eric Harris and Dylan Klebold. Their plans for attacking the school, recovered by investigators after the tragedy had taken place, evolved over one year’s time. In those plans, Klebold and Harris outlined a mission to kill as many students and faculty as possible. They would set off destructive bombs inside the school and then shoot any survivors trying to run out. Bombs inside their cars would explode later, killing law enforcement, fire or medical personnel responding to the scene.

Kate Cooper Case Essay

Green Meadows Hospital is newly constructed community hospital owned by Southern Hospitals Corporation. Kate Cooper was very excited when she got a new position at Green Meadows as a Manager of Adult Services. They started hiring people and were getting ready to open the hospital. However, things did not go well as they planned and wanted to. Therefore, Kate had to resign. The biggest problem that I see in this was their unorganized management skills and communications skills. They should have more prepared since they were new hospital and related to people’s lives but from the beginning, it seemed like they did not think that it was a big of deal and just went it the flow. Communications at Green Meadows Hospital is more likely one way communication. It started out with 2 way communication model somehow, but it ended up having just one way communication model. At first, Alan seemed like he understood Kate’s situation and encouraged her with her getting higher education and seemed like he was going to be a strong supporter. However, it didn’t really work out. It was always him giving her too much work when even she told him that she does not think that she can handle all the responsibilities and works due to her duties and school. Also, There were never really clear communication or/and understanding among Doug, Alan, and Kate. 2 way communication model would have fixed their problems. Even though one way communication is a lot easier and faster, using 2 way communication is more accurate, can make fewer mistakes, and will have fewer problems. They could have asked questions to each other, talk about concerns, and even make suggestions or modifications if they needed to. That would have helped them to understand each other, information that they should know about, and what is being communicated. This could have help them to share information effectively and the team could have performed better. I would have to say that Doug and Alan both have the SIL style of between S1 and S2. They both are somewhat directing and coaching at the same time. They seem like they are listening to their followers but the result shows us that they didn’t really. At first he seemed like he was very encouraging and supporting his followers and he turned out to be very selfish and self-centered leader. To be a S3 or S4 leaders, they need to listen to their followers more since they are working with their patients directly and might know better than them. However, decisions were never made with the followers, instead the leaders made most of the decisions and just announced it. On the other hand, Kate is in the level of D2. She has had some experiences as a charge nurse and a house supervisor. Kate has some relevant skills with the new position but since she was new to this position and to the hospital, she needed some help from her leaders. I would say Peter is in the level of D4. He just knew what he was doing and seemed like very confidence of what he was doing but like Alan, he was very selfish, seemed like he always thought about himself first instead thinking about the team as a whole. To help Kate and Peter, they could change their leaderships to S3. I think S4 would be too much for everyone with this situation, but having 2 way communication, when making decisions followers can be involved, but still the leaders can make the final decisions. Instead of Doug and Alan telling Kate and Peter what to do, they all can be involved and talk about what is going on at the hospital and talk about it to make it better or make a better decisions. Kate and Peter will more feel like they are important and will be more motivated and perform better. First theory is expectancy theory. If people put their effort into something and they perform to get the result. Between putting effort and performing they think that their effort will make them to attain their goals. Also between their performance and outcome, they expect specific result. Maslow’s Need Hierarchy is the next theory. People have to have the low level of needs to have higher needs. Also once a need is satisfied, it is not a powerful motivator anymore. Third is Alderfer’s ERG Theory. This theory is somewhat similar to Maslow’s theory but slightly different. It has three sets of needs: existence, relatedness, and growth. Unlike Maslow’s law ERG theory states that several different needs can be done at once and at the same time because they are all connected. This can either motivate or demotivate people. They should use ERG theory to prevent managers like Kate from resigning. Environment like hospitals should have existence needs, relatedness needs, and growth needs at the same time. They do not have time to wait for one thing to get done and go onto another. At the hospital they work with people. They should respect each other, not just respect the leaders but also leaders should respect the followers. And also they should have relationship that includes all the employees and share their thoughts, discuss problems together, and try to find the solutions together. And people need some kind of motivations to work better with other people, be productive, or perform better. These can happen all at once. However, Kate did not get any respect from her co-worker or her leaders and also did not have any motivations. Alan just kept pushing her to the edge. He did not even ask her opinion and told her what to do. Again, there was no communication between them and that was the main problem tha t they had. a. Absence of Trust – At first, they trust each other, but as time goes by, they didn’t really talk about the problems. They didn’t even try to help each other out. They didn’t talk about when Alan behaved unprofessionally and inappropriately. No body was really getting along well. b. Fear of Conflicts – They should have worked as a team but seems like to me they were just working as an individual. They didn’t respect each other, didn’t care about each other, and ignore some issues that they were having. They didn’t really try to fix problems but just covered up when they should have talked about Alan’s behavior or Peter taking Kate’s orientation dates. c. Lack of Commitment – Since they don’t trust each other, don’t respect each other, it led them to have lack of commitment. No body really knew what they were really doing. Everyone was on their owns. There were no priorities, no directions, and had same problems over and over again: Kate having too much responsibilities and work). d. Avoidance of Accountability – Alan always gave Kate way too much work that she cannot even handle them. Alan and Dough were supposed to be communicating each other and lead them team but even they did not really communicate well and resulted in Alan overstepping Doug’s positions. e. Inattention to results – Because of all of the above, it got to the point where Kate was told that she had to quit school. This clearly shows how Alan’s leadership style and ethics were very wrong. I would say, right now they are in the Storming stage. It is the stage when hostilities and conflicts arise, and people jockey for positions of power and status. They can’t go on to the next stage that is Norming stage if they can’t solve the problems. Peter and Alan being selfish and having a self-centered leadership, having no communication among the team members, giving too much work and all the responsibilities to one manager, leader’s unprofessional/inappropriate behavior should be all solved for them to continue to the Norming stage. At Norming stage, the team members share their ideas, thought, goals, and develop closer relationship, which will lead them to perform better, and success as a whole. For Green Meadows Hospital, the most needed solution is communication. Communication is always important in any kind of situation. If they start communicating as a team, having regular meetings that will build their trust. Trust is also important factor but with out communication, it can’t be built. The leaders should have a heart for the company, should be able to motivate their followers, and should have right ethics. Leaders should not have any deception, fear, pride, or greed. Alan showed a lot of greed and deception in this case (telling Kate to quit school, unprofessional behaviors, not following his leader†¦etc). Of course it is important to have great leadership skills but without a heart, they will have no followers. To have faithful, committed followers, then leaders should do it first.

Founded on economic principles Essay Example

Founded on economic principles Essay Example Founded on economic principles Paper Founded on economic principles Paper The objective of Lu and Comanor’s study is to investigate on the factors that affect the prices of pharmaceutical products at their introduction to the market throughout their life cycle. Their work was founded on economic principles and supported by a regression analysis of empirical data on new drugs introduced from 1978 to 1987. Data on the new molecular entities that were introduced before 1984 were sourced from the Food and Drug Administration (1985), while the rest were from a study of drugs lags between the United States and the United Kingdom. The drugs used as part of the empirical data were subject to the FDA ratings, wherein Class A represented drugs that provided valuable therapeutic gain, Class B were drugs that were modestly effective, and Class C were drugs that gave little or no therapeutic benefits. : One of the main findings was the therapeutic significance of the pharmaceutical products was directly proportional to its launch price. In fact, Class A and B drugs were launched into the market at a premium while most of Class C drugs were at a discount. These findings satisfied previous research, such as Reekie’s (1978). According to Reekie, drugs that were therapeutically advanced were priced higher than substitutes already in the market while imitators cost cheaper. This pricing behavior has led Reekie to conclude that an even price competition in the market cannot be completely possible due to the presence of such advanced patented drugs. He observed, however, that through time, prices of these advanced drugs decline while those of generic or imitation drugs increased (Lu Comanor 108, 111). The empirical data also reveal, Class A drugs have the least imitators while Class C drugs have the most. But despite the production of these supposed imitators, the rate of imitation is not as rampant as those in other industries. In fact, branded rivals still thrive in the market and they cause the decline in the launch prices of fellow innovative drugs, whereas generic substitutes produce the opposite effect. This pricing behavior reflects the findings Dean’s (1969) study wherein he defines two (2) pricing techniques for new products, namely skimming and penetration pricing. Skimming pricing is positioning new advanced therapeutic products at premium prices that eventually decline, and penetration pricing is introducing less innovative products at lower prices and raising them over time. In essence, results of the study show that advanced therapeutic products enter the market under skimming pricing while imitation and other less innovative drugs do so under penetration pricing (Lu Comanor 108, 111). Aside from the pricing strategies, it was interesting to learn how the nature of the diseases also serves as price determinants for the drugs intended to treat them. According to the text, the repurchase or sustainability in demand for the drugs is, somehow determined by whether it is used for acute or chronic cases. So for drugs that are intended for chronic cases, such as those of the elderly, the strategy applied is more price-sensitive. This aspect of the pricing strategy is interesting in that aside from following the dynamics of price and demand, it benefits consumers that continuously need such therapeutic products for their health. While the text effectively incorporates economic principles with the technicalities of the pharmaceutical industry, the discussion on pricing would have been more substantial if the cost side of the products were also considered. As prices of drugs and other health instruments are often topics of debate, it would have been more interesting if the text broadened the discussion to include the price structure of the products and a forecast on the direction of the pharmaceutical industry during this time when the health crises is most prevalent. Reference Lu, John Z., and Comanor, William S. Strategic Pricing of New Pharmaceuticals The Review of Economics and Statistics, Vol. 80, No.1 (Feb., 1998), 108-118

Bouillon vs. Bullion vs. Boolean

Bouillon vs. Bullion vs. Boolean Bouillon vs. Bullion vs. Boolean Bouillon vs. Bullion vs. Boolean By Brittiany Cahoon Dont confuse bouillon with bullionone is a soup ingredient and the other is gold. Both bouillon and bullion come from Old French, and in fact the same root word, boillonwhich refers to the froth on the top of a boiling cauldron. They are pronounced almost the same: Merriam-Webster says that bouillon should be said BOOL-yon, while bullion should be pronounced BULL-yen. But bouillon is a beef broth, like in French cuisine or bouillon soup, and bullion refers to bricks of gold, like in Fort Knox. Thanks to modern technology, we have bouillon cubes: those salty sugar-cube-size morsels that can be dissolved in boiling water for easy soup. But modern technology also gives us Boolean cubes, a graphical visualization of Boolean functionswhich are used in the study of cryptography, for example. If we can assume cubes of bullion make bad soup, I wouldnt risk the Boolean cubes. Here are some quotations from newspapers: CHICKEN FLAVOR GRANULATED BOUILLON , 4-ounce jar (makes 28 cups), 14 cents a pint. Absolutely classic bouillon flavor, not bad for a drink made predominantly of salt and sugar, but little or no relation to chicken. (www.nytimes.com) which operates vaults in London, New York and Zurich there has been a ninefold increase in the number of gold bullion traders in the past five years, with Britons among the most enthusiastic buyers. Most of them, say BullionVault, (www.theguardian.com) Gold Bullion Exchange, accused of bilking investors nationwide of millions of dollars worth of undelivered gold bullion, was stabbed to death today, apparently in an argument over use of his car, police said. (www.nytimes.com) Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Vocabulary category, check our popular posts, or choose a related post below:Definitely use "the" or "a"In Search of a 4-Dot EllipsisWhat the heck are "learnings"?

Vibration monitoring of Gas Turbine in oil industry Essay

Vibration monitoring of Gas Turbine in oil industry - Essay Example Mostly it is used in turbo machinery when in support of fluid film bearings. ii. The Velocity-pickup detectors: It is characterized with a flat response to amplitude which is given as a function of frequency. As a result the alarm setting will remains same as before despite different speeds of the turbine. Their role in the turbines diagnosis is however limited. This pickup detector tends to be very directional providing different result values when subjected to the same force but placed facing in different directions. iii. Accelerometers: This is usually in many cases mounted on the machine’s casing. Their main work is to pick up vibrations problems from the spectrum transmitted between the shaft and the casing. They are used in identification of high frequency response problems which can arise due to, dry fictional whirl, wearing of gear teeth, blade flutter and surge. The industrial gas turbines in oil industries are built and intended for industrial applications as exhibited in their design features. Gas turbine in oil industry utilizes the fluid-film in bearings in both their and axial and radial shaft support. They use seal oil auxiliary systems and conventional lube oil, and also they are used in heavier construction, due to their heavy weight driven components. (Kamboukos et al.2005). Some Gas Turbine Condition Monitoring and Protection System that can be used are: i. Radial Bearings: When two proximity probes are used then they should be placed in a configuration that of X-Y in each of the bearing and observe directly their relative motion from the bearing and the shaft. This has been recommended to be used like a shutdown parameter. ii. Thrust Bearings: Only two proximity probes are used, observation of the axial position in the shaft being at within thrust bearing area of clearance. It is also has been recommended to be used as shutdown parameter. (Loboda et al. 2006). iii. Casing Vibration: The

Air pollution Essay Example | Topics and Well Written Essays - 1500 words

Air pollution - Essay Example This paper will discuss air pollution and its various aspects. According to Lbl.gov, there are various major  kinds  of pollution, which produce renowned  effects on the well-being and health  of individuals and the environment as a whole. These pollution types include the discharge of such toxic gases as chemical vapors, carbon monoxide, sulfur dioxide and nitrogen oxides. Once these gases get into the environment, they can become involved in advanced chemical reactions leading to the formation of  acid rain and  smog. Other serious implications include the development of holes in the ozone layer as well as greenhouse effect. The other type of air pollution, which results from fuel combustion for energy, involves the discharge of  particles  (particulate matter) into the air. These particles are tiny pieces of matter, which measures roughly 0001 inches. An excellent case in point of this  kind of particulate matter is diesel smoke. This kind of pollution is also kn own as black carbon pollution. Smoke from burning fuels in industries, homes, and automobiles, is a main source of air pollution. It is also believed that burning charcoal and wood in barbeques and fireplaces can as well discharge into the air significant amounts of soot. Liu explains that the common sources of air pollution include industrial facilities, motor vehicles emissions, household combustion devices, forest fires, mold spores, and pollen among others. According to him, these sources fall into two main categories, namely natural and human sources (15). The natural sources of air pollution include volcanic activity that lead to the production of ash particulates, chlorine, sulfur, carbon monoxide and smoke from wildfires; and dust from natural sources that are usually large areas with no or little vegetation (Chapman and Rob 23). Human sources of air pollution result from human activities that contribute to air pollution. One of the main sources of air pollution that results from human activity is from manufacturing facilities, waste incinerators, and power plants and other forms of fuel-burning heating devices (Gurjar 33). Aircraft, motor vehicles, sound equipments, and marine vessels are the other sources of air pollution from human activities. Military activities such as toxic gases, nuclear weapons, and germ warfare can be the other source of air pollution. Controlled burn practices and chemicals used in forestry management and agriculture are the other sources of air pollution resulting from human activity (Colls 27). Pollutants are the substances that cause air pollution. Pollutants that are of major public health and environment concern include ozone, sulfur dioxide, particulate matter, nitrogen dioxide, and carbon dioxide (Liu 18). Pollutants are classified into two main categories: primary and secondary. Primary pollutants are those that are emitted directly from a process such as sulfur dioxide from manufacturing facilities, the carbon monoxi de from the motor vehicle, or ash from volcanic eruption (Gurjar 36). Example of primary pollutants include carbon dioxide, nitrogen oxides, volatile organic compounds, ammonia, radioactive pollutants,